ETS-7

WormBase ID: WBGene00017601

WormBase description: Is an ortholog of several human genes including ERG (ETS transcription factor ERG); ETV5 (ETS variant transcription factor 5); and FEV (FEV transcription factor, ETS family member). Is predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Human ortholog(s) of this gene are implicated in acute myeloid leukemia and craniosynostosis.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-TCTAACTCATCATCAGCACGAA-3'

Strain name: SYS497

Cross: OP486 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs486 (ets-7::TY1::EGFP::3xFLAG(92C12) + unc-119(+))

Expression pattern: Lineage-specific, Transient-expression

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): CEH-10, CEH-13, ELT-1, TBX-37, TBX-38, LIN-1, PHP-3, CEH-43


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: TBX-38, CEH-43, ALR-1, CEH-44, ETS-5, HLH-14, K09A11.1, LIM-7, MDL-1, NHR-102, NHR-23, NHR-25, POP-1, RCOR-1, SEL-8, SWSN-7

Targeted by: NA

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: TBX-38, CEH-44, ETS-5, MDL-1, NHR-23, NHR-25, POP-1, RCOR-1, SWSN-7

Targeted by: NA