NHR-85

WormBase ID: WBGene00003675

WormBase description: Is an ortholog of human NR1D2 (nuclear receptor subfamily 1 group D member 2). Is predicted to have several functions, including DNA-binding transcription factor activity; nuclear receptor transcription coactivator activity; and transcription factor binding activity. Is expressed in excretory duct cell; hypodermis; rectal epithelium; and vulva. Human ortholog(s) of this gene are implicated in familial partial lipodystrophy type 3; obesity; and type 2 diabetes mellitus.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-CAGCACCCGTACTTCTTCCA-3'

Strain name: SYS594

Cross: OP539 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs539 (nhr-85::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Not expressed

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NA


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: HAM-2, ZIP-8

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: HAM-2, ZIP-8