SEA-1

WormBase ID: WBGene00004750

WormBase description: Is an ortholog of several human genes including TBX19 (T-box transcription factor 19); TBX22 (T-box transcription factor 22); and TBX6 (T-box transcription factor 6). Exhibits RNA polymerase II regulatory region sequence-specific DNA binding activity. Is involved in dosage compensation by hypoactivation of X chromosome; positive regulation of transcription by RNA polymerase II; and sex determination. Localizes to nucleus. Is expressed in several structures, including coelomocyte; head muscle; intestine; neurons; and ventral nerve cord. Human ortholog(s) of this gene are implicated in several diseases, including X-linked cleft palate with or without ankyloglossia; adrenocorticotropic hormone deficiency; and dysostosis (multiple).

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-CGGAAGCCGAACTTAGACAA-3'

Strain name: SYS560

Cross: OP129 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs129 (sea-1::TY1::EGFP::3xFLAG(92C12) + unc-119(+))

Expression pattern: Transient-expression

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): TBX-37, CEH-39


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: NA

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: NA