HLH-12

WormBase ID: WBGene00001956

WormBase description: Is an ortholog of several human genes including FIGLA (folliculogenesis specific bHLH transcription factor); TCF24 (transcription factor 24); and TWIST2 (twist family bHLH transcription factor 2). Is predicted to have protein dimerization activity. Localizes to nucleus. Is expressed in anterior distal tip cell; linker cell; and posterior distal tip cell. Human ortholog(s) of this gene are implicated in Barber-Say syndrome; ablepharon macrostomia syndrome; and premature ovarian failure.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-ATTTCCGCACATCTTCAACG-3'

Strain name: SYS584

Cross: OP538 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs538 (hlh-12::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Not expressed

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NA


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: NA

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: NA