HLH-17

WormBase ID: WBGene00001961

WormBase description: Is an ortholog of human BHLHE23 (basic helix-loop-helix family member e23). Is predicted to have protein dimerization activity. Is involved in positive regulation of dopaminergic synaptic transmission and positive regulation of transcription by RNA polymerase II. Is expressed in CEPshDL; CEPshDR; CEPshVL; CEPshVR; and ventral cord neurons. Human ortholog(s) of this gene are implicated in congenital malabsorptive diarrhea 4 and persistent hyperplastic primary vitreous.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-AAATCCTGCTGTTCGACTGA-3'

Strain name: SYS585

Cross: OP643 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs643 (hlh-17::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Expressed after bean stage

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NA


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: NA

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: NA