microRNA name: miR-34

WormBase ID: WBGene00003262

WormBase description of miR-34: Involved in several processes, including determination of adult lifespan; negative regulation of autophagy; and response to heat. Expressed in excretory canal; hypodermis; neurons; somatic nervous system; and vulval precursor cell.

Conserved microRNA sequences of miR-34:

D.melanogaster: dme-miR-34

H.sapiens: hsa-miR-34a, hsa-miR-34b*, hsa-miR-34c-5p, hsa-miR-449a, hsa-miR-449b

Location: Intergenic

Promoter length (bp): 1998

Promoter sequence: taaagcccactggtgactcatactcatagaaaagcgaacatcactgcgagactccgcacagcactgtgttgcctgcggcatcgatccttgttgtctatctatctggtcgttcgtcatgagttttctgcattgattgaggcaacgcgtgagagtgtgagagcgggcgaaccatgagttgacgtctctttttccaggcacgtgagtttgacagcagcagcagtagctctctcgcgccacactgaagggcgcgaggttacgaacacacgcgcacagactcgaaggttcttagtagtagaagaagaagacaacacaaaaatatggacgacgacgtttagtttcgagacggcaacacaacgagacggcgacaaaaaaaaagaaattctgcacccttgttctgcagtccgcacactttaggctccatttgttactctgcctcaacttctagtgtttgaacagcgcggcgacaatttttttttccatcgccctgccagcgtcaccaaaattggccattcatttttttttgttgtatgtgttcactttctccaactctctttctagttgtctctgattcgttgtaagacctatttgtgacgtgtcaccgcgactatgcaacaaacgtgtagatagagcgccaccgccctctcttttctgaaagtggcagtagagagaaagagagagagagagagatgcagagataaaaagtagggaatggaaagcgaagagggaggtaaggttttccatcttttcaggcattcctctcttcctcccgcctcgttcgttcgctcttgttgttttgtcactaggccctggggctgtgagcggcccggtcttccattttctgtttatgtgatgtaaaaattgtgaaaaaaataaattttcagttagataggaggacgacaagatagatcgaaaaggagcgggaaacatagatagaggtagagagagagtgagagagagagagaaaagggagtaagaggacaggaacagggtgagaaccccgcctcaagtattttccttgtttttgatcaccactctcatttttcattccccccccccccccacttttttttcaatttcaaacttttcaacatgtagatcaaccatcaatcatcaaatgaattagttctgaattatttgaataattcaattcattttttgaagatactcaaactttgcttgtataagttttcaaatttcacaatctgttcgcattatttgaaacaaatgtagatgataaggcttcacgattggccactaatttatggaagatttttttgaaaaccattttcggagttaactcacagcttggttctagttgatgtatggttagaaattttgtgtgaaaactttatatttttggtgttaacctacttcctgtcaagtgatactagtcatttcgaacatcaggcgtcattatcatacatcaagggaacatcacaagaccagcattcttacataagttgaatccagtgtctcgtggtttgagtttaaaaaaaaagaaaaactcttgtccttggctttcatttgttgaaattatgtctgttaccccgctgaacatcggacgaagacaaatcgacaaaaaaaactccaaacaaaaaacaaatactgggtggctatacatttctccttagtgttttgcatctagtgacattttttgaattaagataccttttgcaatttctactttttccagttacagtgtcaaacttgaatccgttcagtattacgcattcctcaatgttttgaagattaatattcaatctccatgttaactttacttgttattccgaagctatcaattctagctattcaaattatatattttggaaaacaatactttcatttcagccactgcagatgtccaacaaacaactctaaatctccccgtaactatgcgacaggccacagcttccttttttttcccattcaatactttctcgacgttattcaataactactaataccactactgactattattcttataaCGGACAATGC

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Tissue specificity (embryo):

Tissue specificity (L1): Rectum & anus

Number of insertion lines: 5

All strain names: SYS1363, SYS1364, SYS1367, SYS1523, SYS1524

Representative strain name: SYS1524

600-cell stage and L1 stage
The black dots on the lienage tree represent an increase in the fluorescence intensity of miRNAp::mNG::H2B during this cell cycle.

Embryo

L1

Embryonic 3D expression pattern

4-cell

8-cell

15-cell

28-cell

~50-cell

~100-cell

~200-cell

~350-cell

~500-cell

~600-cell

600-cell

bean-stage

L1 3D expression pattern

Left view

Right view

Dorsal view

Ventral view