microRNA name: miR-48

WormBase ID: WBGene00003039

WormBase description of miR-48: Involved in miRNA-mediated gene silencing by inhibition of translation and positive regulation of development, heterochronic. Expressed in P5.p hermaphrodite; P7.p hermaphrodite; RID; and seam cell. Used to study Parkinson's disease.

Conserved microRNA sequences of miR-48:

D.melanogaster: dme-let-7, dme-miR-963, dme-miR-977, dme-miR-984

H.sapiens: hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f, hsa-let-7g, hsa-let-7i, hsa-miR-98

Location: Intergenic

Promoter length (bp): 1502

Promoter sequence: cctacattgacctaatagacaattaggtaggcattttgtgcctacataaaacaaatttaagtactttttgagacccgataacagctcgaaaaacgcatcgtgttgtaggattgttgggttttttgtattgaatataaaaatgaaatgatggttttttaaacaatattcccagccgctgttagatactcttggaaaaaatgaataaatttactgttagcctgagaatggtctaaaattctgaaaaaacaaaacgaatcaaaatgttctacggcaaattttctagctactcattctgatgagtttgcgtttattgttgaagcacttacataaatgttagtagttttatcgatagaccatattttcgatagcacaggaaggaatttgctctgaaaaaattttggtagactaaaaatttaaaaattggagcaactttgtaatgtttcagtttatttgccagctcatttctgaatttttccgcaatttttagaaactagtcttctgcaaatttcttatcataattccttgtaaattattgtaactgttttttctacaagttttatctggcttcagaattattatagttggttgttgttgagacccctgaaacttacttgattgatttttgctacattttttgaaggttttgaatattatttttcacatctctcataatctccaatttgtaaagcgttaaacaacatgggtcattttttagttactagaaattcaagctccgcccctaatgatttcttgaactggagcaagctatcagaattaacttccaatttcagaggaaataggcggagcttattttcagacatctaattcgaaagttttcgaaactctctttttttcgcctgaattgatgttggcaaccggttcccatatcagttcagaacacattatttcgaaataggcacaaagtttaatctcttgaacctctcactatctgtgcttaagaacaggctactgtagcattgagctcacagctgccgtgagttcaaaagatcaattggaacccaccgtaacccaacgcgtttgcctcgaaaactttccaattacaatttctgagggacaaatcgcatcttgcaaacgaaacggaaaagcggatgaaaaaaacgtctgcagctagcatgtctaccttttgatttaatttcgaattctcattcaccttgatgacgataccatcggaagaggtaaaaagaaacagacaggccttcctctccgaaaaatcgaatgaaaaaagtgctacggtagtgtctagccgttagtccgatttgtgggcgccgcccctctctagttccttctgactctcttgcactctctcactatctcttcgctccctccactccgctcccaaacacgtcttcttcttcttttccctcgatccgcttgtctcttcctaccaattcacttttattcattctattatttcactacttattaagtatattgattcccccacaggtaagtcaattaaccaattgAAACTCCCGGGAACT

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Tissue specificity (embryo):

Tissue specificity (L1): Intestine

Number of insertion lines: 5

All strain names: SYS1540, SYS1541, SYS1542, SYS1543, SYS1544

Representative strain name: SYS1542

600-cell stage and L1 stage
The black dots on the lienage tree represent an increase in the fluorescence intensity of miRNAp::mNG::H2B during this cell cycle.

Embryo

L1

Embryonic 3D expression pattern

4-cell

8-cell

15-cell

28-cell

~50-cell

~100-cell

~200-cell

~350-cell

~500-cell

~600-cell

600-cell

bean-stage

L1 3D expression pattern

Left view

Right view

Dorsal view

Ventral view