microRNA name: miR-73 miR-74

WormBase ID: WBGene00003301 WBGene00003302

WormBase description of miR-73: Is affected by several genes including daf-12; eat-2; and glp-4 based on tiling array and RNA-seq studies. Is affected by multi-walled carbon nanotube and graphene oxide based on RNA-seq studies.

WormBase description of miR-74: Is affected by several genes including daf-12; eat-2; and prg-1 based on tiling array and RNA-seq studies. Is affected by Microcystin-LR and sanguinarine based on microarray and RNA-seq studies.

Conserved microRNA sequences of miR-73:

D.melanogaster: dme-miR-31a, dme-miR-31b

H.sapiens: hsa-miR-31

Conserved microRNA sequences of miR-74:

D.melanogaster: dme-miR-31a, dme-miR-31b

H.sapiens: hsa-miR-31, hsa-miR-513b, hsa-miR-873

Location: Intergenic-operon

Promoter length (bp): 2000

Promoter sequence: ttggccaatggggacgaaaagttttcggaacatctcattacttcaggtctatctcattactttcaggtctaaaaaaagcaaagtctcaaatttcggtatcccaccttcaaagcatttccagaatattttagtacaatagtttaatacttgtacaatttaatacatatacttgttttttataatccaaaatttttaaaatttaaacgtatatttatttgcattttaaagattaggaaacaatattttctaaacatgatatatatatatatatatataatatagatcatatataataatatagataatgtgcgtatatatatatatatatatatatgaggggtattgaagtattcaaaaatgtaaaaatggctatgttgttttgaaatttgatgatgaaaaaattgatctgcggtatgttaagctaattaggacaaaactgttactttttcacattgcaatgttaaataataagaatggatgttttccactattcgaatcagactacggcaccgacctacagtaatagccgttaatctcttcttcattcaaatagggcacagtcaaataagataaagagcttggtcaaacaagatcctgtggcctagcacttgggagagcggtcaaaagtgcagtcggagtttgtgataggaatatccagtttcataaacagtaccggttttttgggcattgttggtttattgcggtgtcttttatcttgataaatcactgttagcgatttttaaaggtggagtatttagcgccagaaagtaaattgtttaaaactacttccatagtgctaaaatggccagatatcataggaaaagttgtcaaaatggtttcgaaatatatgcactgccagtcaaaaaaaaagtacttgtgtaacatgcaaaattgaccattttttaaatgttacgtggctctttttatccatattaggtttaggattagttttttatatgccgtgaagcactaatcaatttcacattttgattatattatcattttcaaaaaaaatgaatggaaaacgtattggaaaatatttttcggtcaggtttactacaaaagtacttcaaaaagtggcgatcgctgagtttttgcatgttcgaaattctaaatattgattttttaaacacaagtagactataaaatttgaaggtaacttttttttgattccaaaacttccaaaagtggtataatctgaggttttttaaattttcaaaaaatcatataatatttggaaacattttttgaatttttttagttggttatttggtcattgtggtgtcttaaagtaaattcaccactagtgctactccaccttaaatcgtatttgaaatatcttccgagcgtgcccagctaaaacaatttcgataaaatctgctgttgtctgcgtcaaaatagaaaaaaagaagacaaagacagtttcgatgaaggaccgctgcgttgatttcgatttcgaatgttgcgaccccgaccgttcaaggtaaccctcttttttttcgttggcgcctcgtgtactttcgtttctttttctaccggttctcagcacacaccgcggaggtccatttttcgccttgcaattcattctgcagcgtttttccgtttgaattagtgcaagtcatcagtggttacgtgtatacgcagactggcaggcgttttttgtttacacacgtcatcatcttacgacgtcgtcgtcctttctggtcatttctacttttaatatttgggaaaggggcactactatttacctgccttcttcccatattaggtgggcccttgatgtggacagttggtggcgaacgctgcatttttccattccagagagtagagagtgtgcgggttgaagagagacagacgtcactgcgctcttacacacacacacacacacacacacacacacacacacacacactatcgatccccaacagtcccgcccacatttgtcaacacacggttcttacgacagttgtcccttcatctcactcttcattcatttattc

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Tissue specificity (embryo): Pharynx

Tissue specificity (L1):

Number of insertion lines: 5

All strain names: SYS1368, SYS1527, SYS1528, SYS1546, SYS1547

Representative strain name: SYS1547

600-cell stage and L1 stage
The black dots on the lienage tree represent an increase in the fluorescence intensity of miRNAp::mNG::H2B during this cell cycle.

Embryo

L1

Embryonic 3D expression pattern

4-cell

8-cell

15-cell

28-cell

~50-cell

~100-cell

~200-cell

~350-cell

~500-cell

~600-cell

600-cell

bean-stage

L1 3D expression pattern

Left view

Right view

Dorsal view

Ventral view