EGL-38

WormBase ID: WBGene00001204

WormBase description: Is an ortholog of human PAX5 (paired box 5) and PAX8 (paired box 8). Exhibits RNA polymerase II regulatory region sequence-specific DNA binding activity. Is involved in several processes, including nematode male tail tip morphogenesis; uterus development; and vulval development. Localizes to nucleus. Is expressed in body wall musculature; egg-laying apparatus; head neurons; and ventral nerve cord. Human ortholog(s) of this gene are implicated in several diseases, including WAGR syndrome; diabetes mellitus (multiple); and eye disease (multiple).

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-TCTCGGAACACTCCCACAGC-3'

Strain name: SYS447

Cross: OP171 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs171 (egl-38::TY1::EGFP::3xFLAG(92C12) + unc-119(+))

Expression pattern: Neuronal-specific

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): CEH-6, COG-1, ZAG-1, NHR-25, PAL-1, HBL-1, IRX-1, CEH-36


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: ZIP-8

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: NA