UNC-4

WormBase ID: WBGene00006744

WormBase description: Is an ortholog of human UNCX (UNC homeobox). Exhibits DNA-binding transcription factor activity. Is involved in several processes, including nervous system development; regulation of synapse structure or activity; and synaptic vesicle transport. Localizes to axon and nucleus. Is expressed in neurons and ventral nerve cord. Human ortholog(s) of this gene are implicated in several diseases, including Waardenburg's syndrome (multiple); diabetes mellitus (multiple); and eye disease (multiple).

Reporter verification: Poor sequencing result, verified by comparing expression pattern to the literature (Miller and Niemeyer, 1995)
Primers used to verify fosmid reporter: 5'-AGGCGACCAAATGCGAAATA-3'

Strain name: SYS652

Cross: OP162 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs162 (unc-4::TY1::EGFP::3xFLAG(92C12) + unc-119(+))

Expression pattern: Expressed after bean stage

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NA


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: BLMP-1, UNC-55

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: BLMP-1, UNC-55