PAX-3

WormBase ID: WBGene00003939

WormBase description: Is an ortholog of human PAX3 (paired box 3) and PAX7 (paired box 7). Is predicted to have DNA binding activity. Is involved in hemidesmosome assembly. Is expressed in several structures, including AB lineage cell; E lineage cell; P9/10L; hypodermal cell; and tail. Human ortholog(s) of this gene are implicated in several diseases, including Waardenburg's syndrome (multiple); diabetes mellitus (multiple); and eye disease (multiple).

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-ATTCACTGCCGAGCAACTAG-3'

Strain name: SYS2101

Cross: OP190 x SYS1191

Strain genotype: thu7 (his-72::cherry) III; wgIs190 (pax-3::TY1::EGFP::3xFLAG(92C12) + unc-119(+))

Expression pattern: Lineage-specific, Posterior-biased, Tissue-specific (Skin and Intestine)

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NA


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: ELT-2, LSY-2, NFYA-1, REF-2

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: ELT-2, LSY-2, NFYA-1