CEH-53

WormBase ID: WBGene00015651

WormBase description: Is an ortholog of several human genes including ALX4 (ALX homeobox 4); PROP1 (PROP paired-like homeobox 1); and RHOXF1 (Rhox homeobox family member 1). Is predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Human ortholog(s) of this gene are implicated in several diseases, including WAGR syndrome; diabetes mellitus (multiple); and eye disease (multiple).

Reporter verification: Verified by whole-genome sequencing
Primers used to verify fosmid reporter: nan

Strain name: SYS580

Cross: OP444 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs444 (ceh-53::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Expressed after bean stage (based on Reilly et al. 2020; PMID: 32814896)

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NA


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: CEH-36, ZIP-8

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: NA