MLS-1

WormBase ID: WBGene00003376

WormBase description: Is an ortholog of human TBX1 (T-box transcription factor 1). Is predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding activity; and RNA polymerase II regulatory region sequence-specific DNA binding activity. Is involved in muscle cell fate specification and post-embryonic development. Localizes to nucleus. Is expressed in anal depressor muscle and egg-laying apparatus. Is used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene are implicated in several diseases, including CAKUT2; DiGeorge syndrome; and congenital heart disease (multiple).

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-ATCGTCCAAGAGTTCACATAAT-3'

Strain name: SYS616

Cross: OP686 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs686 (mls-1::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Expressed after bean stage

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NA


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: HLH-8

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: HLH-8