DPL-1

WormBase ID: WBGene00001061

WormBase description: Is an ortholog of human TFDP1 (transcription factor Dp-1) and TFDP2 (transcription factor Dp-2). Exhibits protein C-terminus binding activity and transcription factor binding activity. Is involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter; negative regulation of Ras protein signal transduction; and negative regulation of vulval development. Localizes to nucleus. Is expressed in germ line; gonad; and hyp7 syncytium.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-AAAACGGAACAGCCGATGAC-3'

Strain name: SYS120

Cross: OP365 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs365 (dpl-1::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Not expressed

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NA


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: PHA-4

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: CEH-48, LSY-2, MEP-1, NFYA-1, PHA-4