WormBase ID: WBGene00004013 WormBase description: Is an ortholog of human FOXA2 (forkhead box A2). Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Is involved in several processes, including pharynx development; positive regulation of cellular metabolic process; and response to sodium arsenite. Localizes to nucleus. Is expressed in several structures, including enteric muscle; gonad; neurons; pharynx; and rectum. |
Reporter verification: Verified by PCR and sequencing |
Strain name: RW10425 Strain genotype: unc-119 (ed3) III; itIs37 (pie-1p::mCherry::H2B::pie-1 3'UTR + unc-119(+)); stIs10116 (his-72p::his-24::mCherry::let-858 3'UTR + unc-119(+)); stIs10389 (pha-4::TGF(3E3)::GFP::TY1::3xFLAG) |
Expression pattern: Lineage-specific, Tissue-specific (Pharynx and Intestine) |
Lineage expression pattern 350 stage   |
600 stage  |
3D expression pattern  4-cells  8-cells  15-cells  28-cells  ~50-cells  ~100-cells  ~200-cells  ~350-cells  ~500-cells  ~600-cells  600-cells  bean-stage |
Inferred TF relationships Based on expression similarity (strong, medium, weak): DMD-4, CEH-60, ELT-2, PHA-2, PQM-1, PAX-1, CEH-2, CEH-22, MDL-1, ELT-7, NHR-232, CEH-34, ZFH-2, ODD-2, END-1, CEH-45, DMD-5, AST-1, TBX-7, EYG-1, CEH-27, NHR-102, DVE-1, Y48G1C.6, CEH-51, LIM-7, TTX-1, SEM-2, TBX-2, M03D4.4, MLS-2, LAG-1 Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined) Targeting: DMD-4, PHA-2, CEH-2, CEH-22, MDL-1, CEH-34, ZFH-2, ODD-2, TBX-7, EYG-1, CEH-27, NHR-102, DVE-1, LIM-7, TTX-1, TBX-2, M03D4.4, AHA-1, AHR-1, ALY-1, ALY-2, ARID-1, ATFS-1, ATHP-1, CAMT-1, CEBP-1, CEH-20, CEH-38, CEH-39, CEH-5, CEH-74, CEH-88, CFI-1, CRH-2, DAF-12, DAF-19, DAF-3, DPFF-1, DPL-1, DUXL-1, EFL-1, EFL-3, EGL-18, EGL-44, EGRH-1, EOR-1, ETS-5, F19F10.9, FOS-1, GMEB-1, GMEB-2, HAM-2, HBL-1, HLH-2, HLH-30, HMG-20, HMG-4, K09A11.1, K10B3.5, LIN-13, LIN-15B, LSY-2, MBF-1, MEP-1, MML-1, NFI-1, NFYA-1, NFYC-1, NHR-10, NHR-12, NHR-49, NOB-1, POP-1, RCOR-1, SKN-1, SMA-2, SOX-2, SWSN-7, T07F8.4, UNC-37, Y55F3AM.14, Y73E7A.1, ZTF-6 Targeted by: ELT-2, PHA-2, PAX-1, CEH-2, CEH-34, DVE-1, TBX-2, CEH-18, CEH-19, CEH-83, HLH-1, HLH-30, LSY-2, MEP-1, NFYA-1, SPTF-1, UNC-120, ZIP-8, PQM-1, MDL-1, BLMP-1, C16A3.4, CEH-82, DPL-1, EFL-1, SKN-1, SWSN-7 |
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Targeting: DMD-4, PHA-2, CEH-22, MDL-1, CEH-34, ZFH-2, ODD-2, TBX-7, EYG-1, CEH-27, DVE-1, TTX-1, TBX-2, M03D4.4, AHA-1, AHR-1, ALY-1, ALY-2, ARID-1, ATFS-1, ATHP-1, CAMT-1, CEBP-1, CEH-20, CEH-39, CEH-5, CEH-74, CEH-88, CFI-1, CRH-2, DAF-19, DPFF-1, DPL-1, DUXL-1, EFL-1, EFL-3, EGL-44, EOR-1, ETS-5, F19F10.9, GMEB-1, GMEB-2, HAM-2, HBL-1, HLH-2, HLH-30, HMG-20, HMG-4, K09A11.1, K10B3.5, LIN-13, LIN-15B, LSY-2, MBF-1, MEP-1, MML-1, NFI-1, NFYA-1, NFYC-1, NHR-10, NHR-12, NHR-49, NOB-1, POP-1, RCOR-1, SKN-1, SMA-2, SOX-2, SVH-5, SWSN-7, T07F8.4, UNC-37, Y73E7A.1 Targeted by: ELT-2, PHA-2, CEH-34, TBX-2, CEH-18, CEH-19, CEH-83, LSY-2, NFYA-1, SPTF-1, PQM-1, MDL-1 |
