DUXL-1

WormBase ID: WBGene00022554

WormBase description: Is an ortholog of human DUXA (double homeobox A). Is predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding activity; and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Is expressed in coelomocyte; excretory cell; gonad; and spermatheca.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-ACGCTACCGAAGAGGACGAT-3'

Strain name: SYS431

Cross: OP470 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs470 (duxl-1::TY1::EGFP::3xFLAG(92C12) + unc-119(+))

Expression pattern: Non-specific

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NA


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: CEH-39, CND-1, ELT-2, HLH-30, HMG-4, MEP-1, PHA-4, REF-2, TBX-2, ZIP-8, ZTF-11, CEH-82, DPL-1, EFL-1, LSY-2, MDL-1, RNT-1

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: CEH-39, CND-1, ELT-2, HLH-30, HMG-4, MEP-1, PHA-4, REF-2, TBX-2, ZIP-8, ZTF-11, CEH-82, DPL-1, EFL-1, LSY-2, MDL-1, RNT-1