WormBase ID: WBGene00003163
WormBase description: Is an ortholog of human MXD3 (MAX dimerization protein 3) and MXI1 (MAX interactor 1, dimerization protein). Exhibits protein heterodimerization activity. Contributes to sequence-specific DNA binding activity. Is involved in determination of adult lifespan and regulation of cell differentiation. Localizes to nucleus and transcription factor complex. Is expressed in body wall musculature; neurons; pharynx; and somatic nervous system. Is used to study Parkinson's disease. Human ortholog(s) of this gene are implicated in prostate cancer. |
Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-TTCACCCTGCTACCTGGAGT-3' |
Strain name: SYS103 Cross: OP106 x JIM113 Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs106 (mdl-1::TY1::EGFP::3xFLAG + unc-119(+)) |
Expression pattern: Intestine-specific
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Lineage expression pattern
350 stage
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600 stage
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3D expression pattern  4-cells  8-cells  15-cells  28-cells  ~50-cells  ~100-cells  ~200-cells  ~350-cells  ~500-cells  ~600-cells  600-cells  bean-stage |
Inferred TF relationships
Based on expression similarity (strong, medium, weak): PQM-1, ELT-2, NHR-232, ELT-7, END-1, NHR-102, NHR-12, DVE-1, DPFF-1, ATF-7, PHA-4, CEH-20, F23B12.7, LAG-1, CEH-74, SEL-8, CRH-2, NHR-10
Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)
Targeting: PQM-1, NHR-102, ATF-7, PHA-4, CEH-20, LAG-1, CRH-2, NHR-10, ARID-1, ATFS-1, ATHP-1, BCL-11, CAMT-1, CEBP-1, CEH-38, CEH-39, CEH-44, DAF-12, DAF-3, DMD-5, DUXL-1, EFL-1, EGL-13, EGL-44, EGRH-1, ETS-4, ETS-5, FOS-1, GEI-3, GMEB-1, HAM-2, HLH-11, HLH-30, IRX-1, K09A11.1, LIM-7, LIN-13, LIN-15B, LSY-2, MEF-2, MEP-1, MML-1, NFYA-1, NHR-25, NHR-35, NHR-49, NHR-85, RCOR-1, SDZ-38, SKN-1, SMA-2, SWSN-7, T18D3.7, TBX-2, TLP-1, TTX-1, UNC-3, UNC-37, UNC-62, Y55F3AM.14, ZIP-3
Targeted by: PQM-1, ELT-2, DVE-1, PHA-4, AHR-1, BCL-11, BED-3, BLMP-1, CEH-13, CEH-14, CEH-18, CEH-19, CEH-2, CEH-31, CEH-34, CEH-43, CEH-6, CEH-83, COG-1, ELT-1, ELT-3, ETS-4, ETS-7, EYG-1, HAM-2, HLH-1, HLH-30, HLH-8, HMG-4, K09A11.1, LIN-11, LIN-13, LSY-2, M03D4.4, MEP-1, MLS-2, NFYA-1, NHR-76, PAX-1, PHA-2, PROS-1, REF-2, RNT-1, SPTF-1, SYD-9, TBX-2, TBX-8, UNC-120, UNC-3, UNC-39, UNC-42, UNC-55, UNC-62, ZIP-8, ZTF-11, AHA-1, ALY-2, C16A3.4, CEH-8, CEH-82, DPL-1, DSC-1, EFL-1, EFL-3, EGL-13, FKH-10, FKH-8, FOS-1, IRX-1, LIN-39, MEF-2, NHR-85, PAX-3, SKN-1, SOX-4, SWSN-7, TLP-1, UNC-130, UNC-86, VAB-15 |
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 Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)
Targeting: PQM-1, ATF-7, PHA-4, CEH-20, LAG-1, CRH-2, NHR-10, ARID-1, ATFS-1, ATHP-1, CAMT-1, CEBP-1, CEH-39, CEH-5, DMD-5, DPL-1, DUXL-1, EFL-1, EGL-44, ETS-4, ETS-5, GMEB-1, HAM-2, HLH-11, HLH-30, IRX-1, K10B3.5, LIN-13, LIN-15B, LSY-2, MEF-2, MEP-1, MML-1, NFYA-1, NFYC-1, NHR-25, NHR-35, NHR-49, NHR-85, RCOR-1, SKN-1, SMA-2, SVH-5, SWSN-7, T18D3.7, TBX-2, TLP-1, UNC-37, UNC-62, ZIP-3
Targeted by: ELT-2, DVE-1, PHA-4, AHR-1, BCL-11, BED-3, BLMP-1, CEH-13, CEH-14, CEH-18, CEH-19, CEH-2, CEH-31, CEH-34, CEH-43, CEH-6, CEH-83, COG-1, ELT-1, ELT-3, ETS-4, ETS-7, EYG-1, HAM-2, HLH-1, HLH-30, HMG-4, K09A11.1, LIN-11, LIN-13, LSY-2, M03D4.4, MEP-1, MLS-2, NFYA-1, NHR-76, PAX-1, PHA-2, PROS-1, REF-2, RNT-1, SPTF-1, SYD-9, TBX-2, TBX-8, UNC-120, UNC-3, UNC-39, UNC-42, UNC-55, UNC-62, ZIP-8, ZTF-11, PQM-1, AHA-1, ALY-2, C16A3.4, CEH-8, CEH-82, DPL-1, DSC-1, EFL-1, EFL-3, EGL-13, FKH-10, FKH-8, FOS-1, IRX-1, LIN-39, MEF-2, NHR-85, PAX-3, SKN-1, SOX-4, SWSN-7, UNC-130, UNC-86, VAB-15
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