WormBase ID: WBGene00000584 WormBase description: Is an ortholog of human NKX6-2 (NK6 homeobox 2). Exhibits repressing transcription factor binding activity. Is involved in several processes, including neuron development involved in amphid sensory organ development; oviposition; and regulation of gene expression. Is expressed in several structures, including egg-laying apparatus; head neurons; male-specific anatomical entity; phasmid sensillum; and spermathecal-uterine junction. Human ortholog(s) of this gene are implicated in double outlet right ventricle and spastic ataxia 8. |
Reporter verification: Verified by PCR and sequencing |
Strain name: SYS144 Cross: OP541 x JIM113 Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs541 (cog-1::TY1::EGFP::3xFLAG + unc-119(+)) |
Expression pattern: Lineage-specific |
Lineage expression pattern 350 stage   |
600 stage  |
3D expression pattern  4-cells  8-cells  15-cells  28-cells  ~50-cells  ~100-cells  ~200-cells  ~350-cells  ~500-cells  ~600-cells  600-cells  bean-stage |
Inferred TF relationships Based on expression similarity (strong, medium, weak): MAB-9, NOB-1, PHP-3, EGL-38, CEH-6, NHR-67, UNC-30, VAB-7, CEH-48, PAL-1, HAM-2, HBL-1, TLP-1, CEH-36, ZTF-11, HLH-2 Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined) Targeting: NOB-1, CEH-48, HBL-1, TLP-1, HLH-2, AHR-1, ALY-1, CEBP-1, CEH-20, CEH-38, CEH-39, CEH-44, CRH-2, DAF-12, DAF-19, DAF-3, DMD-5, EGL-18, EGL-46, EGRH-1, ETS-5, FOS-1, GMEB-1, IRX-1, K09A11.1, LAG-1, LIM-7, LIN-13, LIN-22, MDL-1, MEP-1, NFYA-1, NHR-10, NHR-102, NHR-49, POP-1, RCOR-1, SKN-1, SWSN-7, TTX-1, UNC-37, ZFH-2, ZTF-6 Targeted by: CEH-36, CEH-14, NFYA-1, UNC-42, ZIP-8, FKH-10, FKH-8, IRX-1 |
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Targeting: NOB-1, CEH-48, TLP-1, HLH-2, AHR-1, ALY-1, CEBP-1, CEH-20, CEH-39, CRH-2, DAF-19, DMD-5, EGL-18, ETS-5, GMEB-1, IRX-1, LAG-1, LIN-13, MDL-1, MEP-1, NFYA-1, NHR-10, NHR-49, POP-1, RCOR-1, SKN-1, SWSN-7, TTX-1, UNC-37 |
