Single-Cell Protein Expression Atlas of Transcription Factors

CEBP-1

WormBase description: Is an ortholog of several human genes including CEBPA (CCAAT enhancer binding protein alpha); CEBPD (CCAAT enhancer binding protein delta); and CEBPE (CCAAT enhancer binding protein epsilon). Is involved in activation of MAPK activity; axon regeneration; and regulation of nervous system development. Localizes to cytoplasm; nucleus; and synapse. Is expressed in hypodermis; intestine; muscle cell; neurons; and pharynx. Human ortholog(s) of this gene are implicated in acute myeloid leukemia.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-CCGAGCACGACAAGATGAAG-3'

Strain name: SYS451

Cross: OP563 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs563 (cebp-1::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Non-specific

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): AHA-1, EGL-5, SNAI-1, SYD-9, CEH-22, GMEB-1, LIN-39, CEH-16, CEH-40, HLH-1, BAZ-2, CEH-20, RNT-1, NHR-23, M03D4.4, VAB-7, LIN-26, VAB-15, UNC-120, NHR-12, HBL-1, Y56A3A.28, ATF-7, HAM-2, F23B12.7, UNC-62, LIN-1, Y75B8A.6, EYG-1, CES-2, TTX-1

Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: SYD-9, HLH-1, RNT-1, M03D4.4, UNC-120, HAM-2, UNC-62, BCL-11, CEH-14, CEH-18, CEH-19, CEH-31, CEH-34, CHE-1, COG-1, DVE-1, ELT-2, ELT-3, ELT-4, ETS-4, FKH-10, GMEB-2, HLH-30, HMG-4, LIM-6, LSY-2, MEP-1, MLS-2, NFYA-1, NHR-232, PAX-1, PHA-2, PHA-4, PQM-1, PROS-1, REF-2, SPTF-1, TBX-2, TBX-8, UNC-42, UNC-55, ZTF-11, AHA-1, LIN-39, ALY-2, BLMP-1, C16A3.4, CEH-8, CEH-82, DPL-1, DSC-1, EFL-1, EGL-13, FKH-8, FOS-1, IRX-1, LIN-13, MDL-1, MEF-2, NHR-85, PAX-3, SKN-1, SOX-4, SWSN-7, UNC-86, ZAG-1

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data