WormBase ID: WBGene00006778 WormBase description: Is an ortholog of human PROP1 (PROP paired-like homeobox 1). Is predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Is involved in neuron fate specification and positive regulation of transcription by RNA polymerase II. Is expressed in hypodermis; nerve ring; and neurons. Human ortholog(s) of this gene are implicated in several diseases, including WAGR syndrome; diabetes mellitus (multiple); and eye disease (multiple). |
Reporter verification: Verified by PCR and sequencing |
Strain name: SYS86 Cross: wgIs173 x JIM113 Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs173 (unc-42 fosmid::GFP) |
Expression pattern: Neuronal-specific |
Lineage expression pattern 350 stage    |
600 stage  |
3D expression pattern  4-cells  8-cells  15-cells  28-cells  ~50-cells  ~100-cells  ~200-cells  ~350-cells  ~500-cells  ~600-cells  600-cells  bean-stage |
Inferred TF relationships Based on expression similarity (strong, medium, weak): FKH-10, LIM-4, EGL-13, PAG-3, CEH-48, ZAG-1, EGL-46, NGN-1, CEH-30, HLH-3, VAB-3, EGL-44, FKH-2, UNC-30, SPTF-1, ATF-7, HLH-2, ELT-6, CEH-36, ZTF-11, ZIP-8, CRH-2 Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined) Targeting: FKH-10, LIM-4, PAG-3, CEH-48, ZAG-1, EGL-46, UNC-30, HLH-2, CRH-2, APTF-1, AST-1, ATFS-1, ATHP-1, CAMT-1, CEBP-1, CEH-17, CEH-18, CEH-24, CEH-32, CEH-38, CEH-39, CEH-44, CEH-6, CEH-88, CEH-9, CES-2, CFI-1, CND-1, COG-1, DAF-12, DAF-19, DAF-3, DMD-5, EFL-1, EGL-18, EGL-5, EGRH-1, EOR-1, ETS-5, FAX-1, FKH-8, FOS-1, GMEB-1, HBL-1, HLH-11, HLH-30, LAG-1, LIM-7, LIN-1, LIN-11, LIN-13, LSY-2, MDL-1, MEF-2, MEP-1, MML-1, NFI-1, NFYA-1, NHR-102, NHR-49, NHR-6, POP-1, RCOR-1, SDZ-38, SEM-4, SKN-1, SOX-4, SPR-4, SWSN-7, SYD-9, T18D3.7, TAG-68, UNC-3, UNC-37, UNC-62, Y55F3AM.14, Y73E7A.1, Y75B8A.6, ZFH-2, ZTF-6 Targeted by: ZIP-8, CEH-31, LIN-32, LSY-2, NFYA-1, REF-2, FKH-10, CEH-82, EFL-1, SWSN-7, TBX-2 |
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Targeting: LIM-4, CEH-48, ZAG-1, UNC-30, HLH-2, CRH-2, AHA-1, APTF-1, AST-1, ATFS-1, ATHP-1, CAMT-1, CEBP-1, CEH-10, CEH-17, CEH-18, CEH-24, CEH-32, CEH-39, CEH-5, CEH-54, CEH-88, CEH-9, CES-2, CND-1, DAF-19, DAF-3, DMD-5, EFL-1, EGL-5, EOR-1, ETS-5, FAX-1, FKH-8, GMEB-1, HBL-1, HLH-30, K10B3.5, LAG-1, LIN-13, LSY-2, MDL-1, MEF-2, MEP-1, MML-1, NFI-1, NFYA-1, NFYC-1, NHR-49, POP-1, RCOR-1, SDZ-38, SEM-4, SKN-1, SPR-4, SVH-5, SWSN-7, SYD-9, T18D3.7, UNC-37, UNC-62, Y73E7A.1, Y75B8A.6, ZFH-2, ZTF-6 Targeted by: ZIP-8, CEH-31, LIN-32, LSY-2, NFYA-1, REF-2, FKH-10, CEH-82, EFL-1, SWSN-7, TBX-2 |
