CEH-9

WormBase ID: WBGene00000434

WormBase description: Is an ortholog of several human genes including NKX2-6 (NK2 homeobox 6); NKX2-8 (NK2 homeobox 8); and NKX6-2 (NK6 homeobox 2). Is predicted to have DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Is expressed in dorsal nerve cord; head muscle; head neurons; intestine; and ventral nerve cord. Human ortholog(s) of this gene are implicated in double outlet right ventricle and spastic ataxia 8.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-TGTCACGGAGACGCAGGTAG-3'

Strain name: SYS161

Cross: OP202 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs202 (ceh-9::TY1::EGFP::3xFLAG(92C12) + unc-119(+))

Expression pattern: Not expressed

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NA


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: ETS-5, K09A11.1, LIM-7, NHR-102

Targeted by: CEH-36, MEC-3, UNC-42, ZIP-8

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: ETS-5

Targeted by: CEH-36, UNC-42, ZIP-8