WormBase ID: WBGene00003909 WormBase description: Is an ortholog of human GFI1B (growth factor independent 1B transcriptional repressor). Exhibits transcription corepressor activity. Is involved in several processes, including generation of neurons; negative regulation of secretion by cell; and regulation of backward locomotion. Localizes to nucleus. Is expressed in several structures, including P1.aap; P11.aaap; P12.aaap; neurons; and retrovesicular ganglion. Is used to study alcohol use disorder. Human ortholog(s) of this gene are implicated in hypogonadotropic hypogonadism 22 with or without anosmia; hypogonadotropic hypogonadism 7 with or without anosmia; and platelet-type bleeding disorder 17. |
Reporter verification: Verified by whole-genome sequencing |
Strain name: SYS446 Cross: OP154 x JIM113 Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs154 (pag-3::TY1::EGFP::3xFLAG + unc-119(+)) |
Expression pattern: Neuronal-specific |
Lineage expression pattern 350 stage   |
600 stage  |
3D expression pattern  4-cells  8-cells  15-cells  28-cells  ~50-cells  ~100-cells  ~200-cells  ~350-cells  ~500-cells  ~600-cells  600-cells  bean-stage |
Inferred TF relationships Based on expression similarity (strong, medium, weak): MBF-1, TAB-1, UNC-39, UNC-42, CEH-31, Y48G1C.6, CEH-30, HAM-2, TBX-7, HLH-30, CEH-32, SOX-2, CEH-41, Y56A3A.28, BAZ-2, CES-2, CEH-43, NFI-1, EGL-44, Y75B8A.6, ELT-6, LAG-1, CRH-2, ZIP-8, ZTF-11 Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined) Targeting: EGRH-1, ETS-5, LIM-7, NHR-102, RCOR-1, SWSN-7, HLH-30, ATF-7, CAMT-1, CEH-13, DAF-12, DAF-3, EGL-13, FOS-1, HLH-11, KLF-3, LIN-15B, LIN-39, MEF-2, NHR-25, NHR-85, SDZ-38, SNAI-1, TAG-68, UNC-62, Y55F3AM.14 |
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Targeting: CEH-51, ETS-5, RCOR-1, SWSN-7, HLH-30, ATF-7, CAMT-1, CEH-5, K10B3.5, KLF-3, LIN-15B, MEF-2, NHR-25, NHR-85, SNAI-1, UNC-62 Targeted by: NFYA-1 |
