TBX-7

WormBase ID: WBGene00006544

WormBase description: Is predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding activity; and RNA polymerase II regulatory region sequence-specific DNA binding activity.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-AAGGAAACCGAGTTCATCGC-3'

Strain name: SYS106

Cross: OP311 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs311 (tbx-7::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Lineage-specific, Anterior-biased, Pharynx-specific

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): UNC-30, PHA-2, CEH-22, DMD-4, CEH-34, CEH-51, LET-381, PAG-3, PAX-1, TBX-2, ALR-1, PHA-4, UNC-39, HMBX-1, IRX-1, CEH-27, M03D4.4, F23B12.7, LAG-1, Y75B8A.6


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: CEH-44, ETS-5, K09A11.1, LIM-7, NHR-102, RCOR-1, ZTF-6

Targeted by: PHA-4, ZIP-8

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: ETS-5, RCOR-1

Targeted by: PHA-4, ZIP-8