ALR-1

WormBase ID: WBGene00044330

WormBase description: Is an ortholog of human ALX1 (ALX homeobox 1). Exhibits RNA polymerase II regulatory region sequence-specific DNA binding activity. Localizes to nucleus. Is expressed in several structures, including anterior hypodermis; neurons; pseudocoelom; socket cell; and somatic nervous system. Human ortholog(s) of this gene are implicated in several diseases, including WAGR syndrome; diabetes mellitus (multiple); and eye disease (multiple).

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-AACAAAGCAAATTCCGATGC-3'

Strain name: SYS139

Cross: OP200 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs200 (alr-1::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Lineage-specific, Transient-expression

Lineage expression pattern

350 stage


600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): UNC-30, CEH-8, LET-381, TBX-7, UNC-39, CEH-51, UNC-130, VAB-3, CEH-31, Y56A3A.28, FKH-2, HLH-30, CEH-32, ZIP-8, F23B12.7


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: CEH-39, EOR-1

Targeted by: CEH-34, ELT-1, ELT-2, ETS-7, REF-2, UNC-30, UNC-130, BLMP-1, DSC-1, EGL-13, ELT-3, FKH-10, LSY-2

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: CEH-39, EOR-1

Targeted by: CEH-34, ELT-1, REF-2, BLMP-1, EGL-13, ELT-3, FKH-10