EOR-1

WormBase ID: WBGene00001324

WormBase description: Is an ortholog of human ZBTB17 (zinc finger and BTB domain containing 17). Is predicted to have DNA binding activity and DNA-binding transcription factor activity. Is involved in several processes, including determination of adult lifespan; nematode male tail tip morphogenesis; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Localizes to nucleus. Is expressed in several structures, including dorsal nerve cord; gonad; and pharynx. Human ortholog(s) of this gene are implicated in brittle cornea syndrome.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-CAGCGTGCCTTCTCAGTCGT-3'

Strain name: RW10868

Strain genotype: unc-119 (ed3) III; itIs37 (pie-1p::mCherry::H2B::pie-1 3'UTR + unc-119(+)); stIs10116 (his-72p::his-24::mCherry::let-858 3'UTR + unc-119(+)); wgIs80 (eor-1::TGF(9G1)::GFP::TY1::3xFLAG)

Expression pattern: Transient-expression

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NA


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: CEH-31, CEH-34, CEH-39, CEH-48, CEH-83, LSY-2, MEP-1, NFYA-1, PHA-4, UNC-42, ALR-1, ALY-2, BLMP-1, C16A3.4, DPL-1, DSC-1, EFL-1, ELT-3, RNT-1, SKN-1, SWSN-7, TBX-2

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: CEH-31, CEH-34, CEH-39, CEH-48, CEH-83, LSY-2, MEP-1, NFYA-1, PHA-4, UNC-42, ALR-1, ALY-2, BLMP-1, C16A3.4, DPL-1, DSC-1, EFL-1, ELT-3, RNT-1, SKN-1, SWSN-7, TBX-2