WormBase ID: WBGene00001096 WormBase description: Is an ortholog of human VSX1 (visual system homeobox 1). Is predicted to have DNA binding activity. Is involved in positive regulation of defecation rhythm and regulation of transcription, DNA-templated. Localizes to cell projection; cytoplasm; and nucleus. Is expressed in amphid neurons; enteric muscle; and mechanosensory neurons. Human ortholog(s) of this gene are implicated in keratoconus. |
Reporter verification: Verified by PCR and sequencing |
Strain name: SYS172 Cross: OP522 x JIM113 Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs522 (dsc-1::TY1::EGFP::3xFLAG + unc-119(+)) |
Expression pattern: Non-specific |
Lineage expression pattern 350 stage |
600 stage |
3D expression pattern 4-cells 8-cells 15-cells 28-cells ~50-cells ~100-cells ~200-cells ~350-cells ~500-cells ~600-cells 600-cells bean-stage |
Inferred TF relationships Based on expression similarity (strong, medium, weak): HLH-8 Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined) Targeting: HLH-8, ALR-1, ATF-7, ATFS-1, ATHP-1, BCL-11, CAMT-1, CEBP-1, CEH-18, CEH-20, CEH-23, CEH-36, CEH-38, CEH-39, CEH-54, CEH-90, CND-1, CRH-2, DAF-12, DAF-19, DAF-3, DAF-8, DMD-4, DMD-5, EFL-1, EGL-18, EGRH-1, ELT-4, EOR-1, ETS-5, FOS-1, GEI-3, GMEB-1, HBL-1, HLH-11, HLH-2, HLH-30, IRX-1, K09A11.1, LAG-1, LIM-7, LIN-1, LIN-13, LIN-15B, LIN-39, M03D4.4, MDL-1, MEF-2, MEP-1, MLS-1, MML-1, NFYA-1, NHR-10, NHR-102, NHR-186, NHR-49, NHR-6, NOB-1, PHA-2, POP-1, PQM-1, RCOR-1, REF-1, SDZ-38, SEL-8, SEM-4, SKN-1, SOX-2, SOX-4, SWSN-7, SYD-9, T18D3.7, TAG-68, UNC-120, UNC-3, UNC-37, UNC-62, Y55F3AM.14, Y73E7A.1, ZAG-1, ZFH-2, ZTF-11, ZTF-30, ZTF-6 |
Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined) Targeting: HLH-8, ATF-7, ATFS-1, ATHP-1, CAMT-1, CEBP-1, CEH-20, CEH-23, CEH-36, CEH-39, CEH-5, CEH-54, CRH-2, DAF-19, DAF-3, DAF-8, DMD-5, EFL-1, EOR-1, ETS-5, F19F10.9, GEI-3, GMEB-1, HBL-1, HLH-11, HLH-30, IRX-1, K10B3.5, LAG-1, LIN-1, LIN-13, LIN-15B, M03D4.4, MDL-1, MEF-2, MEP-1, MLS-1, MML-1, NFYA-1, NFYC-1, NHR-10, NHR-186, NHR-49, NHR-6, NOB-1, PHA-2, POP-1, PQM-1, RCOR-1, SEM-4, SKN-1, SOX-2, SOX-4, SVH-5, SWSN-7, SYD-9, T18D3.7, UNC-120, UNC-37, UNC-62, Y73E7A.1, ZAG-1, ZFH-2, ZTF-30 |