WormBase ID: WBGene00000223 WormBase description: Is an ortholog of human ATF2 (activating transcription factor 2) and CREB5 (cAMP responsive element binding protein 5). Exhibits mitogen-activated protein kinase binding activity. Is involved in defense response to Gram-negative bacterium; regulation of innate immune response; and regulation of transcription by RNA polymerase II. Localizes to nucleus. Is expressed in body wall musculature; hypodermis; intestine; neurons; and rectal epithelial cell. |
Reporter verification: Verified by PCR and sequencing |
Strain name: SYS495 Cross: OP638 x JIM113 Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs638 (atf-7::TY1::EGFP::3xFLAG + unc-119(+)) |
Expression pattern: Lineage-specific |
Lineage expression pattern 350 stage   |
600 stage  |
3D expression pattern  4-cells  8-cells  15-cells  28-cells  ~50-cells  ~100-cells  ~200-cells  ~350-cells  ~500-cells  ~600-cells  600-cells  bean-stage |
Inferred TF relationships Based on expression similarity (strong, medium, weak): EGL-5, PQM-1, MDL-1, ELT-2, UNC-3, CEH-22, NHR-232, SYD-9, PHA-2, CEH-8, CEH-40, ELT-7, BAZ-2, END-1, NHR-12, CEH-48, NHR-102, CEH-31, UNC-42, CEH-20, VAB-3, ZAG-1, Y56A3A.28, GMEB-1, HBL-1, CES-2, VAB-15, LIN-39, VAB-7, EGL-44, CND-1, HLH-1, SOX-2, CEBP-1, Y75B8A.6, M03D4.4, TBX-2, CRH-2, LIN-26, UNC-62 Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined) Targeting: no-data Targeted by: ELT-2, CND-1, CEH-83, HLH-30, SPTF-1, ZIP-8, MDL-1, TBX-2, ALY-2, BLMP-1, C16A3.4, CEH-90, DPL-1, DSC-1, EFL-1, EGL-13, ELT-3, FKH-8, LSY-2, MEF-2, MEP-1, NHR-85, PAG-3, PAX-3, RNT-1, SKN-1, SOX-4, UNC-130, UNC-86 |
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Targeting: no-data Targeted by: ELT-2, CEH-83, HLH-30, ZIP-8, MDL-1, TBX-2, BLMP-1, C16A3.4, CEH-90, DPL-1, DSC-1, EFL-1, EGL-13, ELT-3, FKH-8, LSY-2, MEF-2, MEP-1, NHR-85, PAG-3, PAX-3, RNT-1, SKN-1, SOX-4, UNC-130, UNC-86 |
