SOX-4

WormBase ID: WBGene00015716

WormBase description: Is an ortholog of human SOX15 (SRY-box transcription factor 15). Is predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Is involved in innate immune response. Human ortholog(s) of this gene are implicated in several diseases, including 46 XY gonadal dysgenesis; PCWH syndrome; and Waardenburg's syndrome (multiple).

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-TTTCAATGCCCATCCAGACT-3'

Strain name: SYS418

Cross: OP517 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs517 (sox-4::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Expressed after bean stage

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NA


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: CEH-2, DAF-19, DMD-5, EGL-18, ETS-5, GMEB-1, HBL-1, HLH-11, K09A11.1, LIM-7, NHR-102, SEL-8, SWSN-7, ZAG-1, ZTF-6

Targeted by: CEH-31, UNC-42, ZIP-8

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: CEH-2, DAF-19, DMD-5, ETS-5, GMEB-1, SWSN-7, ZAG-1

Targeted by: ZIP-8