WormBase ID: WBGene00006881 WormBase description: Is an ortholog of human MSX2 (msh homeobox 2). Is predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Is involved in embryonic morphogenesis; locomotory behavior; and parturition. Localizes to nucleus. Is expressed in several structures, including P1; P12; P2; neuroblasts; and neurons. Human ortholog(s) of this gene are implicated in several diseases, including orofacial cleft 5; parietal foramina; and tooth agenesis. |
Reporter verification: Verified by PCR and sequencing |
Strain name: SYS223 Cross: OP730 x JIM113 Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs730 (vab-15::TY1::EGFP::3xFLAG + unc-119(+)) |
Expression pattern: Lineage-specific, Muscle-specific |
Lineage expression pattern 350 stage      |
600 stage  |
3D expression pattern  4-cells  8-cells  15-cells  28-cells  ~50-cells  ~100-cells  ~200-cells  ~350-cells  ~500-cells  ~600-cells  600-cells  bean-stage |
Inferred TF relationships Based on expression similarity (strong, medium, weak): NOB-1, EGL-5, UNC-3, SYD-9, PHP-3, LIN-1, CEH-20, LIN-39, LIN-26, VAB-7, TLP-1, UNC-62, CEH-40, NHR-23, NHR-25, CEH-30, ELT-1, HLH-1, IRX-1, UNC-120, ATF-7, HBL-1, CEBP-1, Y75B8A.6 Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined) Targeting: LIN-1, TLP-1, UNC-62, HLH-1, ATHP-1, CEH-38, DAF-12, EFL-1, ETS-5, GMEB-1, KLF-3, LAG-1, LIM-7, LIN-13, MDL-1, MEF-2, MEP-1, MML-1, NFI-1, PAX-3, RCOR-1, REF-2, SWSN-7, UNC-37 Targeted by: UNC-62, ELT-1, HLH-1, CEH-36, LSY-2, NFYA-1, UNC-55, IRX-1, BLMP-1, NHR-85, RNT-1 |
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Targeting: TLP-1, UNC-62, HLH-1, ATHP-1, EFL-1, ETS-5, GMEB-1, KLF-3, LAG-1, LIN-13, MDL-1, MEF-2, MML-1, NFI-1, PAX-3, RCOR-1, REF-2, SWSN-7, UNC-37 Targeted by: UNC-62, ELT-1, HLH-1, CEH-36, LSY-2, NFYA-1, UNC-55, IRX-1, BLMP-1, NHR-85, RNT-1 |
