PHP-3

WormBase ID: WBGene00004024

WormBase description: Is an ortholog of human HOXA10 (homeobox A10). Is predicted to have DNA binding activity. Is involved in positive regulation of nematode male tail tip morphogenesis. Is expressed in several structures, including coelomocyte; head neurons; intestine; somatic nervous system; and tail neurons. Human ortholog(s) of this gene are implicated in several diseases, including brachydactyly-syndactyly syndrome; diabetes mellitus (multiple); and dysostosis (multiple).

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-TCCGAAATGGGACACTCT-3'

Strain name: SYS1013

Cross: RW12213 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; php-3(st12213[php-3::TY1::EGFP::3xFLAG]) III

Expression pattern: Lineage-specific, Posterior-biased

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NOB-1, FOS-1, COG-1, VAB-15, VAB-7, EGL-5, UNC-3, TLP-1, PAL-1, NHR-25, LIN-26, NHR-23, NHR-67, NHR-102, HAM-2, HLH-14, CEH-20, HBL-1, LIN-1, ELT-1, UNC-120, Y75B8A.6, ETS-7


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: NA

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: NA