PAL-1

WormBase ID: WBGene00003912

WormBase description: Is an ortholog of human CDX1 (caudal type homeobox 1). Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Is involved in several processes, including ectodermal cell fate commitment; muscle cell fate commitment; and positive regulation of transcription by RNA polymerase II. Localizes to condensed nuclear chromosome. Is expressed in several structures, including ABprpppppaa; enteric muscle; oocyte; rectal epithelial cell; and tail spike.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-GGAAGAGGTAACATACGGACGAA-3'

Strain name: RW10993

Strain genotype: unc-119 (ed3) III; itIs37 (pie-1p::mCherry::H2B::pie-1 3'UTR + unc-119(+)); stIs10116 (his-72p::his-24::mCherry::let-858 3'UTR + unc-119(+)); wgIs94 (pal-1::TY1::eGFP::3xFLAG(P000006_G02))

Expression pattern: Lineage-specific, Muscle-specific, Transient-expression

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): ELT-3, LSL-1, HLH-8, VAB-7, SNAI-1, HND-1, EGL-5, EGL-38, MED-2, HLH-1, LIN-39, PHP-3, UNC-120, TBX-9, TLP-1, COG-1, HMBX-1, CEH-20, UNC-62, M03D4.4, HAM-2, LIN-26, NHR-25, HBL-1


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: UNC-62, LSY-2, NFYA-1, ODD-2, ZIP-8

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: LSY-2, NFYA-1, ZIP-8