WormBase ID: WBGene00006546 WormBase description: Is an ortholog of human EOMES (eomesodermin) and TBR1 (T-box brain transcription factor 1). Exhibits RNA polymerase II regulatory region sequence-specific DNA binding activity. Is involved in embryonic body morphogenesis. Localizes to nucleus. Is expressed in several structures, including ABarpa; Eal; Ear; Epl; and Epr. Human ortholog(s) of this gene are implicated in adrenocorticotropic hormone deficiency; atrial heart septal defect 4; and dysostosis (multiple). |
Reporter verification: Verified by PCR and sequencing |
Strain name: SYS231 Cross: OP636 x JIM113 Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs636 (tbx-9::TY1::EGFP::3xFLAG + unc-119(+)) |
Expression pattern: Lineage-specific, Posterior-biased, Tissue-specific (Muscle and Intestine), Transient-expression |
Lineage expression pattern 350 stage |
600 stage |
3D expression pattern 4-cells 8-cells 15-cells 28-cells ~50-cells ~100-cells ~200-cells ~350-cells ~500-cells ~600-cells 600-cells bean-stage |
Inferred TF relationships Based on expression similarity (strong, medium, weak): ELT-3, END-3, TBX-8, END-1, HND-1, ELT-7, NHR-102, ELT-1, HLH-1, NHR-12, UNC-120, DVE-1, PAL-1, VAB-7, TBX-38, NHR-23, CEH-13, HMBX-1, UNC-62, CEH-20, M03D4.4, NHR-25, TBX-11, CEH-39, CEH-74 Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined) Targeting: no-data Targeted by: NA |
Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined) Targeting: no-data Targeted by: NA |