TBX-11

WormBase ID: WBGene00006547

WormBase description: Is an ortholog of human EOMES (eomesodermin) and TBR1 (T-box brain transcription factor 1). Is predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding activity; and RNA polymerase II regulatory region sequence-specific DNA binding activity. Human ortholog(s) of this gene are implicated in several diseases, including DiGeorge syndrome; congenital heart disease (multiple); and dysostosis (multiple).

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-ACAGCCAAGCACAAGCCAAT-3'

Strain name: SYS150

Cross: OP368 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs368 (tbx-11::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Lineage-specific, Posterior-biased, Transient-expression

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): END-3, TBX-38, TBX-37, CEH-39, NHR-12, RNT-1, ELT-1, END-1, REF-1, TBX-9, T07F8.4, UNC-130, VAB-7, CEH-13, TLP-1, TBX-8


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: ELT-2, ZIP-8

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: ELT-2, ZIP-8