T07F8.4

WormBase ID: WBGene00020320

WormBase description: Is an ortholog of human MIER1 (MIER1 transcriptional regulator); MIER2 (MIER family member 2); and MIER3 (MIER family member 3). Is predicted to have RNA polymerase II repressing transcription factor binding activity; histone deacetylase binding activity; and transcription corepressor activity. Is expressed in gonad; pharynx; and spermatheca.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-GCCAGTAGTTCAGCCTCATT-3'

Strain name: SYS98

Cross: OP478 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs478 (T07F8.4::TY1::EGFP::3xFLAG(92C12) + unc-119(+))

Expression pattern: Lineage-specific, Skin-specific, Transient-expression

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): ELT-3, TBX-37, CEH-8, CEH-39, TBX-38, DPFF-1, GMEB-1, ELT-1, CEH-83, TBX-11, SEL-8


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: LSY-2, MEP-1, NFYA-1, PHA-4, SPTF-1

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: LSY-2, MEP-1, NFYA-1, PHA-4, SPTF-1