WormBase ID: WBGene00000433 WormBase description: Is an ortholog of human RAX (retina and anterior neural fold homeobox). Is predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Is expressed in Z1 and Z4. Human ortholog(s) of this gene are implicated in several diseases, including WAGR syndrome; diabetes mellitus (multiple); and eye disease (multiple). |
Reporter verification: Verified by PCR and sequencing |
Strain name: SYS1048 Cross: OP760 x JIM113 Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs760 (ceh-8::TY1::EGFP::3xFLAG + unc-119(+)) |
Expression pattern: Neuronal-specific |
Lineage expression pattern 350 stage   |
600 stage  |
3D expression pattern  4-cells  8-cells  15-cells  28-cells  ~50-cells  ~100-cells  ~200-cells  ~350-cells  ~500-cells  ~600-cells  600-cells  bean-stage |
Inferred TF relationships Based on expression similarity (strong, medium, weak): MBF-1, PROS-1, ALR-1, CEH-31, UNC-39, CEH-32, CEH-48, SOX-2, SPTF-1, T07F8.4, FKH-2, ATF-7, HLH-30, NFI-1, CES-2, CEH-43, ELT-6, ZIP-8, ZTF-11, CRH-2 Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined) Targeting: CEH-32, CEH-48, HLH-30, CEH-43, CAMT-1, CEBP-1, CEH-23, CEH-38, DAF-12, DAF-3, DMD-5, EFL-1, EGL-13, EGRH-1, ELT-3, ETS-5, FKH-10, FOS-1, GMEB-1, HBL-1, HLH-11, LIM-7, MDL-1, MEF-2, MEP-1, MML-1, NFYA-1, NHR-102, NHR-186, NHR-49, NHR-6, RCOR-1, SDZ-38, SEL-8, SWSN-7, SYD-9, TTX-3, UNC-62, VAB-3, Y55F3AM.14, ZAG-1, ZFH-2, ZTF-6 |
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Targeting: CEH-32, CEH-48, HLH-30, CAMT-1, CEBP-1, CEH-23, CEH-5, DMD-5, EFL-1, ETS-5, GMEB-1, HBL-1, MDL-1, MEF-2, MEP-1, MML-1, NFYA-1, NHR-186, NHR-49, NHR-6, RCOR-1, SVH-5, SWSN-7, SYD-9, TTX-3, UNC-37, UNC-62, VAB-3 |
