FKH-10

WormBase ID: WBGene00001442

WormBase description: Is an ortholog of human FOXJ1 (forkhead box J1). Is predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Is expressed in gonad and pharyngeal neurons. Human ortholog(s) of this gene are implicated in cataract 34 multiple types; congenital aphakia; and persistent fetal circulation syndrome.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-ATTACTGGGCAGTCCATCCT-3'

Strain name: SYS564

Cross: OP377 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs377 (fkh-10::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Neuronal-specific

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): TTX-3, UNC-42, NGN-1, CEH-48, SOX-2


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: CEH-48, AST-1, CEBP-1, CEH-38, CEH-39, ETS-5, LIM-4, NHR-102, ZAG-1, ZFH-2, UNC-42, SOX-2, ALR-1, BCL-11, CEH-27, CEH-32, CEH-44, COG-1, CRH-2, DAF-12, DAF-19, DAF-3, EFL-1, EGRH-1, FOS-1, GMEB-1, HBL-1, HLH-11, HLH-30, LAG-1, LIN-11, MDL-1, MEF-2, MEP-1, MLS-2, NHR-186, NHR-49, RCOR-1, SDZ-38, SEM-4, SKN-1, SOX-4, SWSN-7, UNC-39, Y55F3AM.14, Y73E7A.1

Targeted by: UNC-42, CEH-83, ZIP-8, CEH-8, FKH-8, LSY-2

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: AST-1, CEBP-1, CEH-39, ETS-5, UNC-42, CEH-48, ALR-1, CEH-27, CEH-32, CEH-5, CRH-2, DAF-19, DAF-3, EFL-1, GMEB-1, HBL-1, HLH-30, LAG-1, LIM-4, MDL-1, MEF-2, MLS-2, NHR-186, NHR-49, RCOR-1, SKN-1, SVH-5, SWSN-7, Y73E7A.1, ZFH-2

Targeted by: NA