MEF-2

WormBase ID: WBGene00003182

WormBase description: Is an ortholog of human MEF2D (myocyte enhancer factor 2D). Exhibits sequence-specific DNA binding activity. Is involved in negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; and regulation of acetylcholine secretion, neurotransmission. Localizes to nucleus. Is expressed in several structures, including hypodermis. Is used to study autism spectrum disorder and intellectual disability. Human ortholog(s) of this gene are implicated in autosomal dominant mental retardation 20 and coronary artery disease.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-TCATCAACAAACGGAATCTC-3'

Strain name: SYS590

Cross: OP301 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs301 (mef-2::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Expressed after bean stage

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NA


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: CEH-14, CEH-18, CEH-31, CEH-48, ELT-2, LSY-2, MEP-1, NFYA-1, RNT-1, SPTF-1, TBX-2, UNC-120, UNC-42, UNC-55, UNC-62, ZIP-8

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: CEH-14, CEH-18, CEH-31, CEH-48, ELT-2, LSY-2, MEP-1, NFYA-1, SPTF-1, TBX-2, UNC-120, UNC-42, UNC-55, UNC-62, ZIP-8