CEH-48

WormBase ID: WBGene00015934

WormBase description: Is an ortholog of human ONECUT1 (one cut homeobox 1); ONECUT2 (one cut homeobox 2); and ONECUT3. Is predicted to have DNA binding activity. Is expressed in head; spermathecal-uterine junction; ventral nerve cord; and vulva.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-GCATCTTCATCATCCGCTTCT-3'

Strain name: SYS402

Cross: OP631 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs631 (ceh-48::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Neuronal-specific

Lineage expression pattern

350 stage



600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): FKH-10, UNC-42, DAF-19, LIM-4, EGL-46, UNC-3, CEH-14, EGL-13, TTX-3, LIN-11, ZAG-1, CFI-1, CEH-8, NGN-1, TTX-1, CEH-6, EGL-44, VAB-3, CEH-30, HLH-3, CND-1, NHR-67, COG-1, ATF-7, SOX-2, HLH-2, SPTF-1, CEH-32, UNC-30, CES-2, ELT-6, FKH-2, ZTF-11, CEH-36, CRH-2


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: DAF-19, ALY-1, ATHP-1, CEH-38, CEH-44, CEH-88, DAF-3, DMD-5, DPFF-1, EFL-1, EGL-18, EOR-1, ETS-5, FKH-8, GMEB-1, K09A11.1, LIM-7, LIN-13, MEF-2, MEP-1, NFYA-1, NHR-102, NHR-49, SDZ-38, SPR-4, SWSN-7, SYD-9, ZFH-2

Targeted by: FKH-10, UNC-42, CEH-14, CND-1, COG-1, SPTF-1, CEH-19, CEH-31, CEH-34, HAM-2, MEP-1, NFYA-1, REF-2, SYD-9, TBX-2, EGL-13, ZAG-1, CEH-8, BLMP-1, CEH-82, EFL-1, FKH-8, LSY-2, SWSN-7, UNC-86

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: DAF-19, ALY-1, ATHP-1, CEH-38, CEH-88, DAF-3, DMD-5, DPFF-1, DPL-1, EFL-1, EOR-1, ETS-5, FKH-8, GMEB-1, LIN-13, MEF-2, NFYA-1, NHR-49, SPR-4, SWSN-7, SYD-9, Y56A3A.28

Targeted by: UNC-42, CEH-14, COG-1, SPTF-1, CEH-19, HAM-2, MEP-1, REF-2, FKH-10, EGL-13, ZAG-1, CEH-8, BLMP-1, CEH-82, EFL-1, FKH-8