LIN-11

WormBase ID: WBGene00003000

WormBase description: Is an ortholog of human LHX1 (LIM homeobox 1). Is predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Is involved in several processes, including axonal fasciculation; oviposition; and positive regulation of vulval development. Is expressed in several structures, including head muscle; neurons; somatic nervous system; uterus; and vulva.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-GCTCCACAATTTGCAGTTCC-3'

Strain name: RW10493

Strain genotype: unc-119 (ed3) III; itIs37 (pie-1p::mCherry::H2B::pie-1 3'UTR + unc-119(+)); stIs10116 (his-72p::his-24::mCherry::let-858 3'UTR + unc-119(+)); stIs10472 (lin-11::TGF(7H3)::GFP::TY1::3xFLAG)

Expression pattern: Anterior-biased, Neuronal-specific

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): HLH-4, UNC-3, DAF-19, DMD-5, HLH-14, CEH-48, ZAG-1, TTX-1, CEH-30, EGL-44, HLH-2, ELT-6, ZTF-11, CEH-43, CRH-2


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: DMD-5, AST-1, ETS-5, K09A11.1, LIM-7, MDL-1, NHR-102, SEL-8, UNC-62

Targeted by: CEH-18, LSY-2, NFYA-1, SPTF-1, TBX-2, UNC-42, ZIP-8, BLMP-1, CEH-82, DPL-1, EFL-1, FKH-10, FKH-8

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: DMD-5, ETS-5, MDL-1, UNC-62

Targeted by: CEH-18, LSY-2, NFYA-1