UNC-3

WormBase ID: WBGene00006743

WormBase description: Is an ortholog of human EBF3 (EBF transcription factor 3). Exhibits RNA polymerase II regulatory region sequence-specific DNA binding activity; histone acetyltransferase binding activity; and identical protein binding activity. Is involved in several processes, including dauer larval development; positive regulation of transcription by RNA polymerase II; and regulation of neuron projection development. Localizes to nucleus. Colocalizes with nuclear chromatin. Is expressed in ABalappaap; ABalappaapp; and neurons.

KI information: mNeonGreen knockin at C-terminus

Reporter verification:Verified by comparing expression pattern to the literature (Prasad et al., 1998)

Strain name: SYS148

KI background: JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; unc-3 (ot837 [unc-3::mNeonGreen::AID]) X

Expression pattern: Anterior-biased, Neuronal-specific

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): LIN-11, NOB-1, ZAG-1, VAB-15, HLH-14, CEH-6, EGL-46, CEH-48, CND-1, CEH-13, VAB-3, PHP-3, UNC-30, ATF-7, CEH-20, UNC-62, EGL-44, NHR-25, SOX-2, EFL-3, HLH-2, ZTF-11, ELT-6


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: UNC-62, CRH-2, EGRH-1, ELT-1, ETS-5, K09A11.1, LIM-7, MDL-1, NHR-102, RCOR-1, ZFH-2

Targeted by: CND-1, UNC-62, CEH-31, HMG-4, LSY-2, NFYA-1, UNC-42, UNC-55, BLMP-1, DSC-1, ELT-3, MDL-1, NHR-85, SKN-1, TBX-2

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: UNC-62, CRH-2, ETS-5, MDL-1, RCOR-1

Targeted by: NA