WormBase ID: WBGene00000431 WormBase description: Is an ortholog of human POU3F4 (POU class 3 homeobox 4). Is predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific. Is involved in excretion; transdifferentiation; and water homeostasis. Localizes to cytosol and nucleus. Is expressed in body wall musculature; head neurons; hyp7 syncytium; intestine; and tail neurons. Human ortholog(s) of this gene are implicated in autosomal dominant nonsyndromic deafness 15; hypopituitarism; and sensorineural hearing loss. |
Reporter verification: Poor sequencing result, verified by comparing expression pattern to the literature (Burglin and Ruvkun, 2001) |
Strain name: RW10871 Strain genotype: unc-119 (ed3) III; itIs37 (pie-1p::mCherry::H2B::pie-1 3'UTR + unc-119(+)); stIs10116 (his-72p::his-24::mCherry::let-858 3'UTR + unc-119(+)); wgIs87 (ceh-6::TGF(9H1)::GFP::TY1::3xFLAG)) |
Expression pattern: Lineage-specific, Posterior-biased, Neuronal-specific |
Lineage expression pattern 350 stage    |
600 stage  |
3D expression pattern  4-cells  8-cells  15-cells  28-cells  ~50-cells  ~100-cells  ~200-cells  ~350-cells  ~500-cells  ~600-cells  600-cells  bean-stage |
Inferred TF relationships Based on expression similarity (strong, medium, weak): MAB-9, ZFH-2, EGL-38, UNC-3, COG-1, EYG-1, ZAG-1, LIN-1, CEH-27, CEH-48, CEH-36, CND-1, SOX-2, CES-2, EGL-44, ELT-6, ZTF-11 Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined) Targeting: AST-1, CEH-38, DMD-5, EGL-18, ETS-5, GMEB-1, GMEB-2, HBL-1, HLH-11, K09A11.1, LIM-7, MDL-1, MEP-1, NHR-102, PROS-1, SEL-8, SWSN-7, SYD-9, UNC-62, ZTF-6 |
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Targeting: DMD-5, ETS-5, GMEB-1, GMEB-2, HBL-1, MDL-1, MEP-1, PROS-1, SWSN-7, SYD-9, UNC-62 |
