GMEB-2

WormBase ID: WBGene00010010

WormBase description: Is an ortholog of human GMEB1 (glucocorticoid modulatory element binding protein 1) and GMEB2 (glucocorticoid modulatory element binding protein 2). Is predicted to have DNA binding activity and transcription coactivator activity.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-AAGACGGTCCAGAACCTCCA-3'

Strain name: SYS452

Cross: OP622 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs622 (gmeb-2::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Not expressed

Lineage expression pattern

350 stage


600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NA


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: AST-1, CEBP-1, DAF-19, ETS-5, HLH-2, K09A11.1, LIM-7, NHR-102, SEL-8, TTX-1, UNC-62

Targeted by: CEH-19, CEH-34, CEH-6, CHE-1, CND-1, HAM-2, HMG-4, M03D4.4, MLS-2, PHA-2, PHA-4, REF-2, SPTF-1, ZIP-8

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: CEBP-1, DAF-19, ETS-5, HLH-2, TTX-1, UNC-62

Targeted by: CEH-19, CEH-34, CEH-6, CHE-1, CND-1, HAM-2, HMG-4, M03D4.4, MLS-2, PHA-2, PHA-4, REF-2, SPTF-1