WormBase ID: WBGene00000437 WormBase description: Is an ortholog of human HOXB1 (homeobox B1). Is predicted to have DNA-binding transcription factor activity. Is involved in cell-cell adhesion and embryo development. Localizes to cytoplasm and nucleus. Is expressed in several structures, including egg-laying apparatus; hypodermis; sensory neurons; somatic nervous system; and in male. Human ortholog(s) of this gene are implicated in several diseases, including Athabaskan brainstem dysgenesis syndrome; diabetes mellitus (multiple); and dysostosis (multiple). |
Reporter verification: Verified by PCR and sequencing |
Strain name: JIM356 Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; ujIs153 (ceh-13::TY1::EGFP::3xFLAG + unc-119(+)) |
Expression pattern: Lineage-specific, Posterior-biased, Skin-specific, Transient-expression |
Lineage expression pattern 350 stage   |
600 stage  |
3D expression pattern  4-cells  8-cells  15-cells  28-cells  ~50-cells  ~100-cells  ~200-cells  ~350-cells  ~500-cells  ~600-cells  600-cells  bean-stage |
Inferred TF relationships Based on expression similarity (strong, medium, weak): LIN-22, RNT-1, END-3, UNC-3, CEH-40, CEH-16, LIN-39, LIN-1, UNC-62, CEH-20, ELT-1, NHR-23, ETS-7, GMEB-1, TBX-9, CND-1, UNC-30, NHR-25, LIN-26, TBX-11, IRX-1 Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined) Targeting: CEH-2, DMD-5, ETS-5, K09A11.1, LIM-7, MDL-1, NHR-102, ZTF-6 Targeted by: RNT-1, UNC-62, ELT-1, CND-1, CEH-18, HLH-1, HMG-4, LSY-2, M03D4.4, NFYA-1, TBX-2, UNC-120, UNC-55, IRX-1, BLMP-1, ELT-3, MEP-1, NHR-85, PAG-3, SWSN-7 |
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Targeting: CEH-2, DMD-5, ETS-5, MDL-1 Targeted by: RNT-1, UNC-62, CEH-18, HMG-4, LSY-2, M03D4.4, NFYA-1, TBX-2, UNC-120, UNC-55, IRX-1, BLMP-1, MEP-1, NHR-85, SWSN-7 |
