CEH-40

WormBase ID: WBGene00000461

WormBase description: Is an ortholog of human PBX1 (PBX homeobox 1); PBX2 (PBX homeobox 2); and PBX4 (PBX homeobox 4). Is predicted to have DNA binding activity and DNA-binding transcription factor activity. Is expressed in dopaminergic neurons. Human ortholog(s) of this gene are implicated in holoprosencephaly 4.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-GCAGGAATGATGAACCCATATC-3'

Strain name: SYS180

Cross: OP232 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs232 (ceh-40::TY1::EGFP::3xFLAG(92C12) + unc-119(+))

Expression pattern: Lineage-specific, Tissue-specific (Skin and Muscle), Transient-expression

Lineage expression pattern

350 stage


600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): RNT-1, LIN-22, NHR-35, GMEB-1, SYD-9, NHR-23, CEH-16, LIN-39, NHR-12, LIN-26, CEH-20, BLMP-1, UNC-62, CEH-13, BAZ-2, HAM-2, LIN-1, ELT-1, HBL-1, VAB-15, NHR-25, HLH-1, TLP-1, ATF-7, VAB-7, UNC-120, IRX-1, F23B12.7, CEBP-1, Y75B8A.6, NFI-1, M03D4.4, CEH-74, SEL-8


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: UNC-62, CEH-39, CND-1, ELT-2, TBX-2, UNC-55, ZIP-8, DPL-1, EFL-1

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: UNC-62, CEH-39, CND-1, ELT-2, TBX-2, UNC-55, ZIP-8, DPL-1, EFL-1