FOS-1

WormBase ID: WBGene00001345

WormBase description: Is an ortholog of human FOS (Fos proto-oncogene, AP-1 transcription factor subunit); FOSL1 (FOS like 1, AP-1 transcription factor subunit); and FOSL2 (FOS like 2, AP-1 transcription factor subunit). Exhibits several functions, including enzyme binding activity; identical protein binding activity; and transcription factor binding activity. Is involved in several processes, including basement membrane disassembly; negative regulation of stress response to copper ion; and regulation of transcription by RNA polymerase II. Localizes to RNA polymerase II transcription factor complex. Is expressed in several structures, including gonad; neurons; uterine pi cell; ventral uterine precursor; and vulval cell.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-TACGGTAGCTGGAAAGTTGT-3'

Strain name: SYS448

Cross: OP304 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs304 (fos-1::TY1::EGFP::3xFLAG(92C12) + unc-119(+))

Expression pattern: Non-specific

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): MBF-1, ZFH-2, DVE-1, PHP-3


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: ATFS-1, ATHP-1, CAMT-1, CEBP-1, CEH-20, CEH-38, CRH-2, DAF-12, DAF-19, DAF-3, EFL-1, EGRH-1, ETS-5, GMEB-1, HLH-11, HLH-30, K09A11.1, LIM-7, LIN-13, MDL-1, MEF-2, MEP-1, NHR-10, NHR-102, NHR-186, NHR-35, NHR-49, RCOR-1, SDZ-38, SKN-1, SWSN-7, UNC-37, UNC-62, Y55F3AM.14, ZTF-6

Targeted by: DVE-1, BCL-11, BLMP-1, CEH-18, CEH-19, CEH-2, CEH-31, CEH-34, COG-1, ELT-2, ELT-3, ETS-4, FAX-1, HAM-2, HLH-30, HMG-4, LSY-2, MEP-1, NFYA-1, PAX-1, PHA-4, PQM-1, REF-2, RNT-1, TBX-2, UNC-120, UNC-42, UNC-55, UNC-62, AHA-1, ALY-2, C16A3.4, CEH-8, CEH-82, DPL-1, DSC-1, EFL-1, EGL-13, FKH-10, FKH-8, HLH-4, IRX-1, LIN-13, LIN-39, MDL-1, MEF-2, NHR-85, PAG-3, PAX-3, SKN-1, SOX-4, SWSN-7, UNC-130, UNC-86

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: ATFS-1, ATHP-1, CAMT-1, CEBP-1, CEH-20, CEH-5, CRH-2, DAF-19, DAF-3, EFL-1, ETS-5, F19F10.9, GMEB-1, HLH-30, K10B3.5, LIN-13, MDL-1, MEF-2, MEP-1, NFYC-1, NHR-10, NHR-186, NHR-49, RCOR-1, SKN-1, SWSN-7, UNC-37, UNC-62

Targeted by: BLMP-1