ATFS-1

WormBase ID: WBGene00013878

WormBase description: Is an ortholog of human ATF4 (activating transcription factor 4) and ATF5 (activating transcription factor 5). Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific and mitochondrial sequence-specific DNA-binding transcription factor activity. Is involved in several processes, including mitochondrial unfolded protein response; positive regulation of nematode larval development; and regulation of gene expression. Localizes to mitochondrial matrix. Colocalizes with nucleus.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-AATAGAATAGCAGCAGTTCGGTA-3'

Strain name: SYS592

Cross: OP675 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs675 (atfs-1::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Not expressed

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NA


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: BLMP-1, CEH-18, CEH-31, DVE-1, ELT-3, HLH-1, LSY-2, MEP-1, MLS-2, NFYA-1, PHA-4, PQM-1, TBX-2, UNC-42, UNC-55, ZIP-8

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: BLMP-1, CEH-18, CEH-31, DVE-1, ELT-3, HLH-1, LSY-2, MEP-1, MLS-2, NFYA-1, PHA-4, PQM-1, TBX-2, UNC-42, UNC-55, ZIP-8