ETS-4

WormBase ID: WBGene00017687

WormBase description: Is an ortholog of human SPDEF (SAM pointed domain containing ETS transcription factor). Is predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Localizes to nucleus. Is expressed in several structures, including P1; germ line; head; socket cell; and sperm.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-AGACAGTATGACACGGGCTTAT-3'

Strain name: SYS567

Cross: OP509 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs509 (ets-4::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Expressed after bean stage

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NA


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: CEBP-1, CEH-22, CEH-38, DAF-12, DAF-19, EFL-1, ETS-5, FOS-1, HLH-11, K09A11.1, LAG-1, LIM-7, LIN-13, MDL-1, NFI-1, NHR-102, RCOR-1, SWSN-7, TBX-2, Y55F3AM.14

Targeted by: BLMP-1, ELT-2, ELT-3, HAM-2, HLH-30, PQM-1

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: CEBP-1, CEH-22, DAF-19, EFL-1, ETS-5, LAG-1, LIN-13, MDL-1, NFI-1, RCOR-1, SWSN-7, TBX-2

Targeted by: BLMP-1, ELT-2, PQM-1