FAX-1

WormBase ID: WBGene00001400

WormBase description: Is an ortholog of human NR2E3 (nuclear receptor subfamily 2 group E member 3). Exhibits DNA-binding transcription factor activity and sequence-specific DNA binding activity. Is involved in several processes, including neuron fate specification; regulation of backward locomotion; and regulation of forward locomotion. Localizes to nucleus. Is expressed in several structures, including CEP; hermaphrodite distal tip cell; interneuron; pharyngeal motor neurons; and rect_D. Human ortholog(s) of this gene are implicated in enhanced S-cone syndrome and retinitis pigmentosa 37.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-GTGAGTTGAGCCTGTGGA-3'

Strain name: SYS747

Cross: OP164 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs164 (fax-1::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Expressed after bean stage

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NA


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: DAF-19, DMD-5, ETS-5, FOS-1, K09A11.1, LIM-7, NFI-1, NHR-102, RCOR-1, SDZ-38, SWSN-7, UNC-37

Targeted by: CEH-31, SPTF-1, UNC-42

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: DAF-19, DMD-5, ETS-5, NFI-1, RCOR-1, SWSN-7, UNC-37

Targeted by: CEH-31, SPTF-1, UNC-42