PAX-1

WormBase ID: WBGene00003937

WormBase description: Is an ortholog of human PAX9 (paired box 9). Is predicted to have DNA binding activity. Is expressed in epithelial cell and pharyngeal cell. Human ortholog(s) of this gene are implicated in several diseases, including WAGR syndrome; diabetes mellitus (multiple); and eye disease (multiple).

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-AAACGGAGGAAATAGTTCAAGC-3'

Strain name: SYS104

Cross: OP117 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs117 (pax-1::TY1::EGFP::3xFLAG(92C12) + unc-119(+))

Expression pattern: Pharynx-specific

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): TTX-1, DMD-5, CEH-34, Y48G1C.6, AST-1, CEH-16, CEH-45, TBX-7, PHA-4, M03D4.4, MLS-2, CEH-27, CES-2, Y75B8A.6, CEH-36, LAG-1, CRH-2


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: TTX-1, PHA-4, CEBP-1, CEH-2, CEH-38, EFL-1, ETS-5, FOS-1, LSY-2, MDL-1, MML-1, ZFH-2, ZTF-6

Targeted by: NA

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: TTX-1, CEBP-1, CEH-38, EFL-1, ETS-5, K10B3.5, LSY-2, MDL-1, MML-1, ZFH-2

Targeted by: NA