NHR-6

WormBase ID: WBGene00003605

WormBase description: Is an ortholog of human NR4A1 (nuclear receptor subfamily 4 group A member 1) and NR4A2 (nuclear receptor subfamily 4 group A member 2). Exhibits DNA-binding transcription factor activity and sequence-specific DNA binding activity. Is involved in positive regulation of transcription by RNA polymerase II; regulation of ovulation; and spermathecum morphogenesis. Localizes to nucleus. Is expressed in chemosensory neurons and spermatheca. Human ortholog(s) of this gene are implicated in extraskeletal myxoid chondrosarcoma and late onset Parkinson's disease.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-GCCTTGTAACACGCTTTGAG-3'

Strain name: SYS577

Cross: OP90 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs90 (nhr-6::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Not expressed

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NA


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: CEH-43, CEH-83, ELT-2, HMG-4, SPTF-1, TBX-2, UNC-42

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: ELT-2